{"id":8923,"date":"2026-08-07T08:00:00","date_gmt":"2026-08-07T14:00:00","guid":{"rendered":"https:\/\/enteratelatino.org\/?p=8923"},"modified":"2026-08-06T18:39:52","modified_gmt":"2026-08-07T00:39:52","slug":"identifican-proteina-esencial-para-prevenir-dano-hepatico-y-tumores-con-el-envejecimiento","status":"publish","type":"post","link":"https:\/\/enteratelatino.org\/index.php\/2026\/08\/07\/identifican-proteina-esencial-para-prevenir-dano-hepatico-y-tumores-con-el-envejecimiento\/","title":{"rendered":"Identifican prote\u00edna esencial para prevenir da\u00f1o hep\u00e1tico y tumores con el envejecimiento"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><em>Un equipo del Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) ha identificado un mecanismo que protege al h\u00edgado frente al da\u00f1o asociado al envejecimiento y reduce el riesgo de desarrollar tumores hep\u00e1ticos. En la imagen, los investigadores que han participado en el trabajo. Foto cedida por el CNIC<\/em><\/p>\n\n\n<div id=\"enter-358430574\" role=\"region\" aria-label=\"Advertisements\"><a data-no-instant=\"1\" href=\"https:\/\/mesacountylibraries.org\/\" rel=\"noopener\" class=\"a2t-link\" aria-label=\"digital-2026-Enterate-125th-Anniversary-Celebration-Print-Ad-June-2026_10x10.75\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/enteratelatino.org\/wp-content\/uploads\/2026\/07\/digital-2026-Enterate-125th-Anniversary-Celebration-Print-Ad-June-2026_10x10.75.jpg?fit=600%2C645&#038;ssl=1\" alt=\"\"  srcset=\"https:\/\/i0.wp.com\/enteratelatino.org\/wp-content\/uploads\/2026\/07\/digital-2026-Enterate-125th-Anniversary-Celebration-Print-Ad-June-2026_10x10.75.jpg?w=600&#038;ssl=1 600w, https:\/\/i0.wp.com\/enteratelatino.org\/wp-content\/uploads\/2026\/07\/digital-2026-Enterate-125th-Anniversary-Celebration-Print-Ad-June-2026_10x10.75.jpg?resize=279%2C300&#038;ssl=1 279w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" width=\"600\" height=\"645\"   \/><\/a><\/div>\n\n\n<p class=\"wp-block-paragraph\">Madrid, 6 ago (EFE).- Un equipo del Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) ha identificado un mecanismo que protege al h\u00edgado frente al da\u00f1o asociado al envejecimiento y reduce el riesgo de desarrollar tumores hep\u00e1ticos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El trabajo ha demostrado que una prote\u00edna mitocondrial (la &#8216;OMA1&#8217;), que se activa ante el estr\u00e9s celular, es capaz de prevenir la enfermedad cr\u00f3nica de h\u00edgado, incluyendo la sobreactivaci\u00f3n del sistema inmune, la fibrosis hep\u00e1tica y el c\u00e1ncer de h\u00edgado.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Los resultados, que se han publicado en The EMBO Journal, muestran que la p\u00e9rdida de esa prote\u00edna desencadena una cascada de acontecimientos que comienza con estr\u00e9s oxidativo y lesi\u00f3n de los hepatocitos -las principales c\u00e9lulas del h\u00edgado- y evoluciona hacia inflamaci\u00f3n persistente, fibrosis, agotamiento de las c\u00e9lulas inmunitarias y una mayor incidencia de tumores primarios de h\u00edgado en modelos experimentales.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La enfermedad cr\u00f3nica de h\u00edgado es responsable de la muerte de dos millones de personas al a\u00f1o, lo que representa el 4 por ciento de la mortalidad en el mundo, y el envejecimiento es un factor determinante en la progresi\u00f3n de esta enfermedad, que sin el correcto tratamiento progresa a cirrosis o c\u00e1ncer con el paso de los a\u00f1os, ha informado el CNIC en una nota de prensa difundida hoy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El h\u00edgado est\u00e1 sometido de forma continua a agresiones derivadas del metabolismo, la alimentaci\u00f3n o el envejecimiento, y cuando estos procesos se mantienen en el tiempo pueden favorecer la aparici\u00f3n de enfermedad hep\u00e1tica cr\u00f3nica, una de las principales causas de cirrosis y carcinoma hepatocelular en todo el mundo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As\u00ed, comprender los mecanismos que preservan la integridad del tejido hep\u00e1tico constituye un objetivo prioritario para el desarrollo de nuevas estrategias terap\u00e9uticas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">En este estudio, los investigadores analizaron durante el envejecimiento ratones modificados gen\u00e9ticamente para carecer de esa prote\u00edna, y aunque los animales alcanzaban la edad adulta sin alteraciones aparentes, con el paso del tiempo desarrollaban lesiones hep\u00e1ticas progresivas, fibrosis y una incidencia significativamente mayor de tumores primarios de h\u00edgado, acompa\u00f1adas de una reducci\u00f3n de la supervivencia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El trabajo, liderado por Jos\u00e9 Antonio Enr\u00edquez, l\u00edder del Grupo de Gen\u00e9tica Funcional del Sistema de Fosforilaci\u00f3n Oxidativa en el CNIC, demuestra que las alteraciones aparecen mucho antes del desarrollo de los tumores.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Los investigadores observaron que la ausencia de esa prote\u00edna modifica la capacidad de los hepatocitos para interactuar con el sistema inmunitario, incrementando la denominada inmunogenicidad del h\u00edgado.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Como consecuencia, los linfocitos T -gl\u00f3bulos blancos que trabajan para eliminar c\u00e9lulas infectadas- se activan de forma persistente hasta alcanzar un estado de agotamiento funcional, caracterizado por la p\u00e9rdida progresiva de su capacidad para eliminar c\u00e9lulas an\u00f3malas o potencialmente tumorales.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Adem\u00e1s de aportar nuevos conocimientos sobre los mecanismos que impulsan la enfermedad hep\u00e1tica cr\u00f3nica y el c\u00e1ncer de h\u00edgado durante el envejecimiento, el estudio tiene implicaciones para el desarrollo de nuevas terapias, ha destacado el CNIC.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Y en ese sentido, ha se\u00f1alado que la prote\u00edna &#8216;OMA1&#8217; puede ser una posible diana farmacol\u00f3gica en distintas patolog\u00edas relacionadas con la funci\u00f3n mitocondrial, aunque los investigadores han incidido en que cualquier estrategia destinada a inhibir esta prote\u00edna deber\u00e1 evaluar cuidadosamente sus posibles efectos sobre el h\u00edgado y el sistema inmunitario.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un equipo del Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) ha identificado un mecanismo que protege al h\u00edgado frente al da\u00f1o asociado al envejecimiento y reduce el riesgo de desarrollar tumores hep\u00e1ticos. En la imagen, los investigadores que han participado en el trabajo. Foto cedida por el CNIC Madrid, 6 ago (EFE).- Un equipo [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":8924,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[1513],"tags":[1626,1918,1539,1522],"class_list":["post-8923","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud","tag-ciencia-y-tecnologia","tag-envejecimiento-investigacion","tag-investigacion-medica","tag-sanidad-y-salud"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Identifican prote\u00edna esencial para prevenir da\u00f1o hep\u00e1tico y tumores con el envejecimiento - Enterate Latino<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/enteratelatino.org\/index.php\/2026\/08\/07\/identifican-proteina-esencial-para-prevenir-dano-hepatico-y-tumores-con-el-envejecimiento\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identifican prote\u00edna esencial para prevenir da\u00f1o hep\u00e1tico y tumores con el envejecimiento - Enterate Latino\" \/>\n<meta property=\"og:description\" content=\"Un equipo del Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) ha identificado un mecanismo que protege al h\u00edgado frente al da\u00f1o asociado al envejecimiento y reduce el riesgo de desarrollar tumores hep\u00e1ticos. 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